A chronic low-grade (indolent) type of lymphoma due to a malignant clone of plasma cells. These plasma cells multiply out of control, invade the bone marrow, lymph nodes, and spleen, and characteristically produce huge amounts of a large-sized antibody called macroglobulin or IgM. The excess IgM causes the blood to be hyperviscous (to thicken).
Waldenstrom macroglobulinemia can occur in younger people but is usually seen in people over age 65. The disease is more common among men than women and among whites than blacks.
Signs and symptoms of the disease may include enlarged lymph nodes or spleen (splenomegaly), fatigue, headaches, weight loss, a tendency to bleed easily, visual problems, confusion, dizziness, and loss of coordination. The symptoms are largely due to the thickening of the blood. In extreme cases, the increased concentration of IgM in the blood can lead to heart failure.
The treatment depends upon the viscosity of the patient’s blood. Patients with pronounced hyperviscosity usually receive chemotherapy (anticancer drugs). A type of treatment called plasmapheresis may be performed to relieve symptoms such as excessive bleeding and dizziness. In this procedure, the blood plasma (which contains the antibody IgM) is removed from the patient. Other parts of the blood (red blood cells, white blood cells, and platelets) are returned to the patient along with a plasma substitute. Interferon alpha, a form of biological therapy, may also help relieve symptoms.
- Walking pneumonia
PubMed Health.com. Atypcial Pneumonia.
1. Having exotropia — divergent strabismus — in which the eyes turn outward away from the nose. The Japanese term is ron-pari, as one eye is looking at Rondon (London) and the other is looking at Pari (Paris). 2. Having a dense white opacity (leukoma) of the cornea. 3. Having large staring eyes, like those […]
1. To move unsteadily; an unsteady motion. 2. To feel nauseated; a feeling of nausea. 3. (Of a stomach) To rumble or growl. From the Middle English wamelen (to feel nausea), from the Indo-European root wem- (to vomit), the source of the words such as vomit and emetic.
A small hard nodule produced by the larva of a fly that has penetrated the skin. The warble can be erythematous (reddened). The most common complication is a secondary bacterial infection around the warble. The usual treatment is to extract the larva by gentle pressure and forceps.
- Warburg apparatus
A device used in biochemistry for measuring breathing (respiration) by tissues. Tissue slices are enclosed in a chamber in which the temperature and pressure are monitored, and the amount of gas produced or consumed by the tissue is measured. The Warburg apparatus was invented by the German biochemist Otto Heinrich Warburg (1883-1970), a pioneer in […]