Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks.
Warfarin works by suppressing the production of some clotting factors (interfering with prothrombin activation) and thereby inhibiting the clotting of blood.
Warfarin interacts with many other drugs, including some vitamins. These interactions can be dangerous, even life-threatening. If you are taking Warfarin, talk to your doctor before taking any other prescription or over-the-counter medications.
University of Wisconsin biochemistry professor Karl Paul Link and his co-workers first isolated dicoumarin, a molecule in spoiled sweet clover that causes cattle to hemorrhage and die. The discovery led to the synthesis of Dicumarol, the first anticoagulant drug that could be taken orally. The successor to Dicumarol was Warfarin.
Warfarin is named after WARF, the Wisconsin Alumni Research Foundation, to which Professor Link assigned the patent. Warfarin was originally marketed as a rodenticide (the rats bleed to death). Its effectiveness in controlling pestilent rats and mice led to great commercial success. Warfarin has, in addition, become the most widely prescribed anticoagulant drug for people and saved countless lives.
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The anticoagulant warfarin (COUMADIN) is a known teratogen, an agent that can disturb the development of the embryo and fetus and lead to birth defects.. Warfarin taken by a woman during pregnancy can cause bleeding into the baby’s brain (cerebral hemorrhage), underdevelopment (hypoplasia) of the baby’s nose and stippling of the ends (the epiphyses) of […]
- Warshaw, Joseph
(1936-2003) Eminent American pediatrician and pioneer in human developmental biology. Warshaw used biochemical, cell biological and molecular techniques to investigate the regulation of fetal growth and perinatal adaptation. Dr. Warshaw began working in the area of developmental metabolism while at Harvard Medical School and Massachusetts General Hospital from 1967 to 1973. He moved to Yale […]
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- Wart, genital
A wart that is confined primarily to the moist skin of the genitals. These warts are due to viruses belonging to the family of human papilloma viruses (HPVs) which are transmitted through sexual contact. The virus can also be transmitted from mother to baby during childbirth. Most people infected with HPV have no symptoms but […]
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Warts that grow on the soles of the feet. Plantar warts are different from most other warts. They tend to be flat and cause the buildup of the top layer of the skin (that has to be peeled away before the plantar wart itself can be seen. They can be quite painful. Plantar warts are […]