Zollinger-Ellison syndrome


Tagamet] and ranitidine [Zantac]) and the proton pump inhibitors (for example, lansoprazole [Prevacid] and omeprazole [Prilosec]). The H2 antagonists block the action of histamine on stomach cells, thus reducing stomach acid production. The proton pump inhibitors also block the production of acid by the stomach cells. Proton pump inhibitors are more effective than H2 antagonists in suppressing acid and have to be used in very high doses. Surgical removal of the tumor is curative in about 25% of cases.

The syndrome is named for two American surgeons Robert M. Zollinger (1903-1992) and Edwin H. Ellison (1918-1970).

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