acting in opposition; opposing, especially mutually.
hostile; unfriendly.
Contemporary Examples

In Canada, relations between the federal system and the provincial system are much more fraught — often antagonistic.
Why Doesn’t Canada Have a Two Party System? David Frum October 5, 2012

First, we enjoy a denial so implausible it verges on the antagonistic, then a grudging acknowledgment of the facts of the matter.
What Tiger’s Mom Saw Lizzie Skurnick December 4, 2009

No matter how antagonistic the question or the barb, Jackson keeps a low voice and a respectful tone.
Obama’s Big Green Gun Michelle Cottle November 1, 2011

Ironically, Hezbollah and its backer Iran have not always had an antagonistic relationship with al-Qaeda.
Hezbollah, Jabhat al-Nusra Set for Showdown in Syria Jamie Dettmer March 13, 2013

It was bad enough in America, with all the agencies involved, which led to some antagonistic moments among them in Katrina.
Haiti’s Grisly Problem Cyril Wecht January 18, 2010

Historical Examples

The interview had been, on the whole, antagonistic; yet the impression it left on her mind was pleasant.
Meg’s Friend Alice Abigail Corkran

Then it came, in the jeering laughter of the antagonistic Dalis.
Astounding Stories of Super-Science July 1930 Various

This man, whose attitude when he saw her in secret at Boscombe was so antagonistic, was now deeply in love with her!
The Place of Dragons William Le Queux

To neglect it, to be indifferent to it, is worse and more foolish than to be antagonistic.
The Good Housekeeping Marriage Book Various

There was a little pride about him which was antagonistic to the best interests of such a trade as his.
The Duke’s Children Anthony Trollope

in active opposition
mutually opposed

1630s, from antagonist + -ic. Related: Antagonistical (1620s); antagonistically.

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