Amyloidosis
A group of diseases that result from the abnormal deposition of a protein, called amyloid, in various tissues of the body. Amyloid protein can be deposited in a localized area, and it may not be harmful or it may affect only a single tissue of the body. This form of amyloidosis is called localized amyloidosis. Amyloidosis that affects tissues throughout the body is referred to as systemic amyloidosis. Systemic amyloidosis can cause serious changes in organs throughout the body. Amyloidosis can occur as its own entity or secondarily, as a result of another illness, including multiple myeloma, chronic infections (such as tuberculosis or osteomyelitis), or chronic inflammatory diseases (such as rheumatoid arthritis and ankylosing spondylitis).
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- Amyloidosis, primary
A disorder of plasma cells (special white blood cells that produce antibodies), this is one of a group of diseases (called amyloidosis) in which protein deposits (amyloid) accumulate in one or more organ systems in the body. Primary amyloidosis is the most common type of amyloidosis in many countries including the U.S. The protein deposits […]
- Amyloidosis, hereditary
A familial (inherited) disorder in which protein deposits (amyloid) accumulate in one or more organ systems in the body. Hereditary amyloidosis is a relatively uncommon cause of amyloidosis. The more common forms of amyloidosis are primary an secondary amyloidosis. However, hereditary amyloidosis is found worldwide. It occurs in families of nearly every ethnic background. The […]
- Amyloidosis, secondary
One of a group of diseases (called amyloidosis) in which protein deposits (amyloid) accumulate in one or more organ systems in the body, secondary amyloid is caused by a chronic infection or inflammatory disease such as rheumatoid arthritis, familial Mediterranean fever, osteomyelitis, or granulomatous ileitis. The protein deposits in this type of the disease are […]
- Amyotrophic lateral sclerosis (ALS)
ALS usually leads to death within 5 years of the time the diagnosis of ALS is made; the range is from 2 to 7 years.
- Amyotrophic lateral sclerosis 1
ALS1. A form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal dominant manner and caused by mutation in the superoxide dismutase-1 gene (SOD1) on chromosome 21q22.1. About 15 to 20% of familial ALS is type 1 (ALS1). Sporadic cases of ALS are sometimes due to new mutation in the SOD1 gene.