CREST syndrome: A limited form of scleroderma, a disease of connective tissue that involves the formation of scar tissue (fibrosis) in the skin and sometimes also in other organs of the body. ‘CREST’ is an acronym for Calcinosis (the formation of tiny deposits of calcium in the skin), Raynaud’s phenomenon (spasm of the tiny artery vessels that supply blood to the fingers, toes, nose, tongue, or ears), Esophagial dysmotility (esophageal involvement by the scleroderma), Sclerodactyly (localized thickening and tightness of the skin of the fingers or toes), and Telangiectasias (dilated capillaries that form tiny red areas, frequently on the face and hands and in the mouth, behind the lips).
- Creutzfeldt-Jakob disease (CJD)
There is currently no single diagnostic test for CJD. When CJD is suspected, the first concern is to rule out treatable forms of dementia such as encephalitis (inflammation of the brain) or chronic meningitis. A neurological examination and spinal tap are often performed to rule out more common causes of dementia. An electroencephalogram (EEG) to […]
- Crib death
Crib death: The sudden and unexpected death of a baby with no known illness, typically affecting infants from 2 weeks to 6 months of age while sleeping. Crib death is now called Sudden Infant Death Syndrome (SIDS). Babies at an increased risk for SIDS include those with a brother or sister who died of SIDS; […]
Crick: 1. A painful sudden spasmodic stiffness in the muscles of the neck or back. 2. Francis Crick who, with James Watson, devised the Watson-Crick model of DNA as a double helix. See: Crick, Francis.
- Crick, Francis
Crick, Francis: British biologist (1916-2004) who shared the 1962 Nobel prize in Medicine and Physiology with James Watson and Maurice Wilkins for “discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material.” The discovery of the structure of DNA as a double helix by Watson and Crick (with […]
- Crick-Brenner experiment
Crick-Brenner experiment: An elegant and important experiment performed in 1961 by Francis Crick and Sydney Brenner. The experiment proved that the genetic code was a triplet code and that the triplets were not separted by “punctuation.” Crick and Brenner demonstrated that a triplet of bases in the DNA determines an amino acid unit and a […]