Gene, Med1 DNA repair: A gene that codes for one of the key enzymes involved in repairing DNA. The DNA in genes is constantly mutating and being repaired. This repair process is controlled by special genes. A mutation in a DNA repair gene such as Med1 can cripple the repair process and cause a cascade of unrepaired mutations in the genome that lead to cancer.
- Gene, regulatory
Gene, regulatory: A gene that regulates the expression of other genes. A regulatory gene is a nosy gene whose prime preoccupation is to horn in on other genes and control the rate at which they make products.
- Gene, suicide
Gene, suicide: A gene whose expression in a cell is lethal for that cell. Suicide genes form the basis of a strategy for making cancer cells more vulnerable, more sensitive to chemotherapy. The approach has been to attach parts of genes expressed in cancer cells to other genes for enzymes not found in mammals that […]
- Gene, transporter
Gene, transporter: A gene that allows drugs to enter cells or, in some cases, acts to keep them out. Transporter genes may account for discrepancies in the way drugs such as antidepressants, anticonvulsants, and chemotherapy agents work in different people. Also known as a drug-transporter gene.
- Gene, Y-linked
Gene, Y-linked: A gene on the Y chromosome. (Y-linkage is analogous to X-linkage (the presence of a gene on the X chromosome) in that it says a gene is on one of the sex chromosomes.) It has often been said that little is known about genes that may be Y-linked. This is no longer true. […]
- Gene, zygotic lethal
Gene, zygotic lethal: A gene that is fatal for the zygote, the cell formed by the union of a sperm and an egg. The zygote would normally develop into an embryo, as instructed by the genetic material within the unified cell. However, a zygotic lethal gene kills prenatal development at its earliest point. A zygotic […]