Genome, Vibrio cholerae: The genome of the bacterium that causes cholera. This genome contains over 4 million bases in its DNA including the sequences for nearly 4,000 genes.
The Vibrio cholerae genome is remarkable in that it is arranged in two circular chromosomes. The larger of the two chromosomes has the usual housekeeping genes, similar to those, for example, of E. coli, the common colon bacillus. The smaller chromosome contains many of the genetic elements that make Vibrio cholerae pathogenic (capable of causing disease).
Genomic: Pertaining to the genome, all of the genetic information possessed by any organism. There are, for instance, the human genome, the elephant genome, the mouse genome, the yeast genome, etc. Humans and many other higher animals have two genomes, namely: A chromosomal genome which is in the nucleus of the cell; and A mitochondrial […]
- Genomic imprinting
Genomic imprinting: The phenomenon of parent-of-origin gene expression. The expression of a gene depends upon the parent who passed on the gene. For instance, two different disorders – Prader-Willi syndrome and Angelman syndrome — are due to deletion of the same part of chromosome 15. When the deletion involves the chromosome 15 that came from […]
- Genomic library
Genomic library: A collection of clones that is made from a set of randomly generated overlapping DNA fragments and that represents the entire genome of an organism. Also known as clone bank.
- Genomic segment
Genomic segment: A region of the genome; it encompasses objects described as loci or probes. Genomic segments can range in size from points to regions as large as an entire chromosome. There are many types of genomic regions. On a technical level, they include genes, gene elements, amplimers (PCR markers), breakpoints in chromosomes, clones, cytogenetic […]
Genomics: The study of genes and their function. Genomics aims to understand the structure of the genome, including the mapping genes and sequencing the DNA. Genomics examines the molecular mechanisms and the interplay of genetic and environmental factors in disease. Genomics includes: Functional genomics — the characterization of genes and their mRNA and protein products. […]