One of the genetic diseases known as neurocutaneous disorders, which cause characteristic patterns of discolored skin and also involve the brain, eyes, nails, and hair. The disease is caused by the genomic rearrangement of the gene for NEMO, or nuclear factor kappa B essential modulator (IKBKG-IKK gamma). Symptoms include discolored skin that appears within two weeks of birth. Neurological abnormalities can include slow motor development, seizures, mental retardation, visual problems, and muscle weakness. Other key features of IP include dental and nail abnormalities. IP is inherited as an X-linked dominant trait, and most affected male fetuses do not survive. In females with IP and certain other X-linked conditions, the X chromosome with the mutant allele is preferentially inactivated; this phenomenon is termed nonrandom (or skewed) X-chromosome inactivation. Also known as Bloch-Sulzberger syndrome.
- Incubation period
In medicine, the time from the moment of exposure to an infectious agent until signs and symptoms of the disease appear. For example, the incubation period of chickenpox is 14-16 days. In biology, the incubation period is the time needed for any particular process of development to take place. For example, the length of time […]
In biotechnology. an apparatus in which environmental conditions can be set and controlled. Incubators are used in microbiology for culturing (growing) bacteria and other microorganisms. Incubators in tissue culture rooms are used for culturing stem cells, lymphocytes, skin fibroblasts and other types of cells. And in the hospital nursery and newborn intensive care unit (NICU), […]
Not amenable to a cure. Incapable of being cured, healed and made well again. From the word cure, from the Latin cura meaning care, concern or attention.
One of the three tiny bones in the middle ear. Sound impulses coming from the eardrum are conveyed from the malleus to the incus and from the incus to the stapes at the oval window to the inner ear. Incus is Latin for anvil.
- Index case
A person who first draws attention to his or her family because of having a medical condition. For example, if an eye doctor discovers a person has glaucoma, and subsequently other cases of glaucoma are found in the person’s family, that person is the index case. Also known as propositus (if male) or proposita (if […]