An abnormal chromosome 17 with two identical long (q) arms due to duplication of the long arm and loss of the short arm. Isochromosome 17q is the most common isochromosome in cancer. It plays an important role in tumor development and progression. Hematologic malignancies such as chronic myeloid leukemia (CML) with isochromosome 17q carry a poor prognosis. Isochromosome 17q is the most common chromosome abnormality in primitive neuroectodermal tumors and medulloblastoma. Isochromosome 17q is, by convention, symbolized as i(17q).
The breakpoint in chromosome 17 that permits the formation of isochromosome 17q is in band 17p11.2 within a region with large, palindromic, low-copy repeat sequences. This complex genomic architecture suggests that isochromosome 17q arises not as a random event but rather due to a susceptibility in the genomic structure.
A remarkable situation in which both chromosomes in a pair are from one parent only. Isodisomy causes some birth defects and is suspected to play a role in cancer. Also known as uniparental disomy.
A type of plant estrogen (phytoestrogen) found chiefly in soybeans.
A protein that has the same function as another protein but which is encoded by a different gene and may have small differences in its sequence. For example, transforming factor beta (TGF-B) exists in three versions, or isoforms (TGF-B1, TGF-B2, and TGF-B3), each of which can set off a signaling cascade that starts in the […]
To separate from others as during an infectious disease.
- Isometric exercise
Exercise involving muscular contractions without movement of the involved parts of the body. Isometric exercise is one method of muscular exercise. In contrast, isotonic exercise occurs when a contracting muscle shortens against a constant load, as when lifting a weight. Isometric comes from the Greek “iso-“, equal + “metron”, measure = maintaining the same measure, […]