A disorder characterized by painless symmetrical diffuse deposits of fat beneath the skin of the neck, upper trunk, arms and legs.
The condition is thought to be genetic although its exact mode of inheritance is uncertain; it may be a mitochondrial DNA disease. It frequently appears in association with alcoholic liver disease, macrocytic anemia (“low blood” with big red blood cells) and peripheral neuropathy (disease of the peripheral nervous system, as opposed to the brain and spinal cord). The peripheral neuropathy has often been laid to alcoholism, but the neuropathy is likely an integral part of the syndrome.
This disorder affects mainly men and is more frequent in the Mediterranean area. It has been suggested that the distribution of fat in cephalothoracic lipodystrophy resembles that of a pre-Roman (6th century BC) Italic statue called the Capestrano warrior discovered in the Abruzzi region of Italy.
Cephalothoracic lipodystrophy is also known as multiple symmetrical lipomatosis, the Launois-Bensaude syndrome and Madelung disease. It was called ‘fat neck’ (Fetthals) by Madelung in 1888.
- Lipoidosis, sphingomyelin
the classical infantile form (type A), the visceral (organ) form (type B), the subacute or juvenile form (type C), the Nova Scotian variant (type D), and the adult form (type E). The disease is named for the German physicians Albert Niemann (1880-1921) and Ludwig Pick (1868-1944). Other names for the disease include sphingomyelinase deficiency.
A benign tumor of adipocytes (fat cells). Lipomas are common in the skin and are found anywhere on the body. They may be surgically removed for cosmetic reasons.
- Lipomatosis, multiple symmetric
A disorder characterized by painless symmetrical diffuse deposits of fat beneath the skin of the neck, upper trunk, arms and legs. The condition is thought to be genetic although its exact mode of inheritance is uncertain. It may be a mitochondrial DNA disease. It frequently appears in association with alcoholic liver disease, macrocytic anemia (“low […]
Peripheral neuropathy is when the peripheral nerves (as compared to the spinal cord or brain) become the source of pain. One way to look at pain is whether it is in response to an appropriate stimulus, such as someone stepping on your toe, or whether the pain occurs for no obvious reason; malfunctioning of the […]
A molecule that is a combination of lipid and protein. Lipids do not travel in the blood by themselves, but they are carried through the bloodstream as lipoproteins.