An unusual anatomic feature that is of serious medical or cosmetic consequence to the patient. For example, a major anomaly might be a cleft lip and palate.
By contrast, a minor anomaly is an unusual anatomic feature not of serious medical or cosmetic consequence to the patient. For example, a minor anomaly might be curvature of the second toe so it overlaps the third toe.
- Major anxiety disorder
panic disorder; obsessive-compulsive disorder; PTSD (post-traumatic stress disorder); social phobia; specific phobias such as claustrophobia; and generalized anxiety disorder.
- Major depression
A disease with certain characteristic signs and symptoms that interferes with the ability to work, sleep, eat, and enjoy once pleasurable activities. The characteristic signs and symptoms of major depression include loss of interest in activities that were once interesting or enjoyable, including sex; loss of appetite (anorexia) with weight loss or overeating with weight […]
- Major gene
A gene that is necessary and sufficient by itself to cause a condition. For example, the APC gene is a major gene for colorectal cancer.
- Major histocompatibility complex
Abbreviated MHC. A cluster of genes located on chromosome 6 concerned with antigen production and critical to the success of transplantation. The MHC includes the human leukocyte antigen (HLA) genes.
Poor intestinal absorption of nutrients. Malabsorption can occur from diseases that injure the bowels, such as Crohn’s disease, Whipple’s disease, celiac disease, and many others.