Maturity onset diabetes of the young
MODY1 is caused by mutation in the hepatocyte nuclear factor-4-alpha gene (HNF4A) on chromosome 20.
MODY2 is caused by mutation in the glucokinase gene (GCK) on chromosome 7.
MODY3 is caused by mutation in the hepatic transcription factor-1 gene (TCF1) on chromosome 12q24.2.
MODY4 is caused by mutation in the insulin promoter factor-1 gene (IPF1) on chromosome 13q12.1.
MODY5 is caused by mutation in the gene encoding hepatic transcription factor-2 (TCF2) on chromosome 17cen-q21.3.
MODY6 is caused by mutation in the gene encoding neurogenic differentiation 1 (NEUROD1) on chromosome 2q32.
Note that genes for MODY are on at least 6 different chromosomes. But two forms, MODY1 and MODY3, are due to mutations in genes that encode hepatocyte nuclear factors (HNF) — transcription factors that govern the expression of other genes.
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