A common genetic risk factor for thrombosis (clots) including deep venous thrombosis (DVT). This mutation in the gene encoding the clotting factor prothrombin is found in about 1 in 50 persons in the US. It raises the risk of thrombosis significantly for both males and females in all age groups.
Prothrombin mutation G20210A gives rise to slowed mRNA degradation and to an increase in circulating prothrombin levels. This appears to create a hypercoagulable state.
The mutation is inherited in an autosomal dominant manner. If someone has the mutation, the chance is 50% that each of their sibs and children also received the mutation. Testing for prothrombin mutation G20210A is therefore useful in determining a person’s predisposition to thrombosis and can assist in determining the need for anticoagulant therapy.
People who have prothrombin mutation G20210A have a 2-to-3 fold increase in the risk of DVT. Persons who have this mutation plus the Factor V Leiden mutation have a 10-to-20 fold increase in thrombotic risk. Prothrombin mutations have also been linked with thrombotic events other than DVT, including recurrent miscarriage (repeat spontaneous abortions). In addition, there may be interactions with other risk factors for thrombosis, including pregnancy, the use of oral contraceptives, and immobilization.
- Prothrombin time
Coumadin, Panwarfin, Sofarin). It measures the time needed for clot formation after thromboplastin and calcium are added to plasma. Familiarly known as pro time.
A normal gene which, when altered by mutation, becomes an oncogene that can contribute to cancer. Proto-oncogenes may have many different functions in the cell. Some proto-oncogenes provide signals that lead to cell division. Other proto-oncogenes regulate programmed cell death (apoptosis). The defective versions of proto-oncogenes, known as oncogenes, can cause a cell to divide […]
- Proton magnetic resonance spectroscopic imaging
Magnetic resonance spectroscopic imaging.
A parasitic single-celled organism that can divide only within a host organism. For example, malaria is caused by the protozoa Plasmodium.
Toward the beginning, the nearer of two (or more) items. For example, the proximal end of the femur is part of the hip joint, and the shoulder is proximal to the elbow. The opposite of proximal is distal. For a more complete listing of terms used in medicine for spatial orientation, please see the entry […]