A shunt (tube) placed between the portal vein which carries blood from the intestines to the liver and the hepatic vein which carries blood from the liver back to the heart. It is used primarily (but not exclusively) in patients with cirrhosis in which the scar tissue within the liver has blocked the flow of blood passing through the liver from the portal vein to the hepatic vein. The blockage increases the pressure in the portal vein leading to an increase in pressure in the portal vein (portal hypertension). As a result of the increase in pressure, blood flows around the liver via small, unimportant veins that connect the portal vein with other veins within the abdomen. These veins enlarge and are referred to as varices.
Unfortunately, one of the places varices form is in the stomach and lower esophagus, and these varices have a tendency to bleed massively, frequently causing death from exsanguination. By providing an artificial path for blood traveling from the intestines, through the liver, and back to the heart, TIPS reduces the pressure in the varices and prevents them from rupturing and bleeding. There are several types of shunts that are placed surgically. TIPS is a non-surgical way of placing a portosystemic shunt. The shunt is passed down the jugular vein in the neck by a radiologist using x-ray guidance. The shunt then is inserted between the portal and hepatic veins within the liver.
The process by which the genetic code carried by messenger RNA (mRNA) directs the production of proteins from amino acids.
- Translocation 11 childhood leukemia
A new type of childhood leukemia in which a piece of chromosome 11 has been translocated (broken off and attached itself to another chromosome).Position 11q23 is the site of the mixed lineage leukemia gene – a gene so called because it has a gene expression profile different from that seen in other leukemias such as […]
- Translocation, reciprocal
A type of chromosome rearrangement involving the exchange of chromosome segments between two chromosomes that do not belong to the same pair of chromosomes. A specific reciprocal translocation might, for example, involve the swap of material between chromosomes 1 and 19.
- Translocation, Robertsonian
A relatively very common and medically significant type of chromosome rearrangement that is formed by fusion of the whole long arms of two acrocentric chromosomes (chromosomes with the centromere near the very end). One in about 900 babies is born with a Robertsonian translocation making it the most common kind of chromosome rearrangement known in […]
- Transmissible spongiform encephalopathy
kuru; Creutzfeldt-Jakob disease; Gerstmann-Straussler syndrome; fatal familial insomnia; variant Creutzfeldt-Jakob disease (vCJD).