14 million pre-school children have some eye damage due to VAD;
350 000 (or more) pre-school children become partially or totally blind every year from VAD;
About 60% of these children die within a few months of going blind;
VAD is associated with an increase in the severity of infections, particularly measles and diarrheal disease;
Through synergism with measles infection, VAD contributes to the estimated 1.1 million childhood deaths from measles every year;
Half of all childhood corneal blindness in developing countries is caused by vitamin A deficiency, and half of that is from added measles infection.
Improving the vitamin A status of deficient children and treating cases of measles with vitamin A can reduce childhood morbidity and mortality substantially. Taking into account the results of eight randomized controlled community supplementation trials, one report concluded that improving the vitamin A status of young children reduced mortality rates by about 23%. Studies from Ghana and Brazil have also indicated that vitamin A supplementation was associated with a decrease in disease severity. In three studies of children hospitalized with measles, vitamin A supplementation reduced the death rate by about 60%.
- Vitamin B -- nicotinic acid
Mental disorientation, confusion, delusions and depression Death, if untreated. Pellagra, once a puzzle, was solved by Joseph Goldberger (1874-1929). Serving in the Public Health Service, Dr. Goldberger proposed that pellagra was due to a nutritional deficiency and in 1915 began experiments with Mississippi prison inmates (who “volunteered” in return for full pardons). Dr. Goldberger fed […]
- Vitamin B -- pantothenic acid
This is one of the less well known B vitamins, perhaps because it is widely distributed in nature. Pantothenic acid is virtually ubiquitous. It is present in foods as diverse as poultry, soybeans, yogurt, and sweet potatoes. No naturally occurring disease due to a deficiency of pantothenic acid has been identified, due to the plentifulness […]
- Vitamin B1
An essential factor in the formation of blood clotting factors. Deficiency can lead to abnormal bleeding.
- Vitamin B12
A vitamin important for the normal formation of red blood cells and the health of the nerve tissues. Undetected and untreated vitamin B12 deficiency can lead to anemia and permanent nerve and brain damage. Pernicious anemia is a blood disorder caused by inadequate vitamin B12 in the blood. Patients who have this disorder do not […]
- Vitamin B12-responsive methylmalonicaciduria
methylmalonicaciduria, long chain ketonuria, and intermittent hyperglycinemia.) Some but not all patients with methylmalonicaciduria respond to vitamin B12. An enzyme called methylmalonyl-CoA mutase is defective in the disease. This enzyme requires the presence of adenosylcobalamin, a form of vitamin B12. The metabolic block in methylmalonic acidemia occurs at methylmalonyl-CoA mutase and can be caused by […]