methylmalonicaciduria, long chain ketonuria, and intermittent hyperglycinemia.)
Some but not all patients with methylmalonicaciduria respond to vitamin B12. An enzyme called methylmalonyl-CoA mutase is defective in the disease. This enzyme requires the presence of adenosylcobalamin, a form of vitamin B12. The metabolic block in methylmalonic acidemia occurs at methylmalonyl-CoA mutase and can be caused by defects in the mutase itself, or in the synthesis of the mutase cofactor adenosylcobalamin. There is also an extraordinarily benign form of methylmalonicaciduria due to deficiency of methylmalonyl-CoA mutase.
The gene for this enzyme (methylmalonyl-CoA mutase) has been mapped to chromosome 6 in region 6p21.1-p12 and has been cloned. More than 30 different mutations in the gene have been identified, each causing methylmalonicaciduria.
- Vitamin B15
An old name for dimethylglycine (DMG, pangamic acid), which is no longer considered to be a vitamin by the strict definition of that word.
- Vitamin B2
1.7 mg (Intakes may be adjusted according to a physician’s instructions.) A milligram equals 1/1000 of a gram. A gram equals .0353 of an ounce. Side Effects From Overdose of Vitamin B2 Vitamin B2 is not known to cause overdose side effects because excessive amounts are not retained by the body. Interactions of Vitamin B2 […]
- Vitamin B3
Mental disorientation, confusion, delusions and depression Death, if untreated. Pellagra, once a puzzle, was solved by Joseph Goldberger (1874-1929). Serving in the Public Health Service, Dr. Goldberger proposed that pellagra was due to a nutritional deficiency and in 1915 began experiments with Mississippi prison inmates (who “volunteered” in return for full pardons). Dr. Goldberger fed […]
- Vitamin B5
Vitamin B5 is pantothenic acid, one of the less well known B vitamins, perhaps because it is widely distributed in nature. Pantothenic acid is virtually ubiquitous. It is present in foods as diverse as poultry, soybeans, yogurt, and sweet potatoes. No naturally occurring disease due to a deficiency of pantothenic acid has been identified, due […]
- Vitamin B6
A group of closely related chemical compounds with related names — pyridoxine, pyridoxal and pyridoxamine — that are transformed within the body to yet another form of vitamin B6, pyridoxal phosphate, that acts as a coenzyme. (A number of vitamins serve as coenzymes, substances that enhance the action of enzymes and thereby aid in catalyzing […]