A chronic, diffuse, unremitting sensation of burning of the vulva — (the female external genital organs including the labia, clitoris, and entrance to the vagina)– a painful sensation which may extend to the perineum, thigh or buttock and is often associated with discomfort in the urethra and rectum. Vulvodynia means “painful vulva.”
Essential vulvodynia occurs primarily in postmenopausal women. There are no reliable data on the prevalence of essential vulvodynia.
The main symptom is pain, usually a sensation of burning, irritation or rawness of the genitals. The pain is quite variable. It can vanish as suddenly as it started. The main finding demonstrable on a medical physical examination is hyperesthesia.
The cause of essential vulvodynia is unknown. There is some evidence that damage to the nerves, particularly the pudendal nerve, supplying this area may play a role.
The prognosis without treatment or spontaneous remission may be for unceasing pain, leading to poor quality of life. Rarely, frequency of micturition (urination), stress incontinence, and chronic constipation may also develop.
Many treatments have been tried. These include drugs such as amitriptyline, nerve blocks (to numb the vulvar nerves), decompression of the pudendal nerve, and biofeedback therapy (to relax pelvic muscles). At present there is insufficient evidence to document any benefit from amitriptyline or pudendal nerve decompression for women with essential vulvodynia.
This is a seemingly minor disease of major consequence for a woman’s quality of life. It is a condition of unknown cause without a proven mode of treatment.
Leukoencephalopathy with vanishing white matter, an inherited brain disease that occurs mainly in children. and follows a chronic progressive course with additional episodes of rapid deterioration following stress from febrile infection or minor head trauma. VWM is due to mutations in either of two genes — in either the EIF2B5 gene on chromosome 3q27 or […]
Brand name for doxycycline.
Capable of life. For example, a viable premature baby is one who is able to survive outside the womb.
Von Hippel-Lindau. See Von Hippel-Lindau syndrome.
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A chronic low-grade (indolent) type of lymphoma due to a malignant clone of plasma cells. These plasma cells multiply out of control, invade the bone marrow, lymph nodes, and spleen, and characteristically produce huge amounts of a large-sized antibody called macroglobulin or IgM. The excess IgM causes the blood to be hyperviscous (to thicken). Waldenstrom […]