A premature aging disease that begins in adolescence or early adulthood and results in apparent old age by 30’40 years of age. Characteristic features include short stature, premature graying, early baldness, wizened face, beaked nose, cataracts, skin changes reminiscent of those in scleroderma, deposits of calcium beneath the skin, premature arteriosclerosis, and a tendency to diabetes and to tumors (especially osteosarcoma and meningioma). Werner syndrome is inherited in an autosomal recessive manner and is due to mutation in the WRN gene on chromosome 8, which encodes RecQ DNA helicase, an enzyme that catalyzes the unwinding of DNA.
- Werner-His disease
184-189, 1999). The organism (B. quintana) that causes trench fever also has been found responsible for a disease called bacillary angiomatosis in people infected with HIV and for infection of the heart and great vessels (endocarditis) with bloodstream infection. Trench fever is also called Wolhynia fever, shin bone fever, quintan fever, five-day fever, Meuse fever, […]
- West Nile fever
A febrile disease caused by the West Nile virus that is transmitted from birds to the common Culex mosquito and then to people. The virus is named after the area it was first found in Uganda. West Nile fever occurs in parts of Africa and Asia and, infrequently, in Southern Europe and the Middle East. […]
- West Nile virus
The mosquito-borne virus that causes West Nile fever. One of the flaviviruses, a family of viruses also responsible for dengue, yellow fever, and tick-borne encephalitis virus. Like the other flaviviruses, the West Nile virus is a positive-strand RNA virus containing three structural proteins and a host-derived lipid bilayer. The West Nile virus is an icosahedral […]
- West syndrome
Infantile spasms, a seizure disorder of infancy and early childhood with the onset predominantly in the first year of life of myoclonic seizures, hypsarrhythmia (abnormal, chaotic electroencephalogram), and mental retardation. The spasms are sudden, brief contractions of one or more muscle groups, and may be followed by a longer (less than 10 seconds) tonic phase. […]
- Western blot
A technique in molecular biology that is used to separate and identify particular proteins.