ZAP-70
Zeta-chain-associated protein kinase 70. A member of the protein tyrosine kinase family, ZAP-70 is normally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling. ZAP-70 is expressed in T cells and tumors of T-cell lineage. A high level of ZAP-70 expression appears restricted to T-cell proliferative diseases and a subgroup of chronic lymphocytic leukemia (CLL). The ZAP-70 gene is in chromosome 2q12.
Read Also:
- Z chromosome
A sex chromosome in certain animals, such as chickens, turkeys, and moths. In humans, males are XY and females XX, but in animals with a Z chromosome, males are ZZ and females are WZ.
- Asparagine
Asparagine: An amino acid, one of the 20 building blocks of protein. Asparagine is nonessential to the diet since the body can synthesize it. Asparagine is important to the metabolism of ammonia. It was the first amino acid to be isolated from a natural source, asparagus juice (1806). Symbol: Asn.
- Microduplication 22q11.2 syndrome
A syndrome due to duplication of a tiny part of chromosome band 22q11.2. Features of the syndrome include the appearance of widely spaced eyes and superior placement of eyebrows; downslanting palpebral fissures (eye slits); mild micrognathia (small chin) and retrognathia (recessed chin); and a long, narrow face. The microduplication arises because chromosome band 22q11.2 is […]