An informal name for a molecular cell biology system of signals or “address tags” that guide the movement of a protein within a cell. In more technical terms, protein ZIP codes* are molecular signals that direct the protein from the endoplasmic reticulum, where it is assembled, to the cytoplasm of the cell and into other cellular compartments such as the nucleus of the cell.
Mutations in this molecular system of protein “ZIP codes” have been found to cause several human genetic (hereditary) disorders, including cystic fibrosis and hyperoxaluria (a disorder that causes a special type of stone to form in the urine beginning in childhood).
In 1999 Dr. Gunter Blobel of the Rockefeller University in New York received the Nobel Laureate in Medicine or Physiology for his discovery of this protein signal system of “ZIP codes.”
* For the benefit of viewers not familiar with the United States mail system, the term “ZIP code” refers to address codes of the U.S. Postal Service used to sort mail into geographic regions.
A gene that encodes a protein called zinc finger protein 9. An inherited mutation in ZNF9 causes type 2 myotonic dystrophy. One region of the ZNF9 gene has a particular 4-base-pair sequence, CCTG, that is normally repeated a few times. (Base pairs are the building blocks of DNA.) This region is called a tetranucleotide repeat. […]
- Zoll, Paul M.
American cardiologist (1911-1999) and pioneer in the development of the cardiac monitor, pacemaker and defibrillator.
- Zollinger-Ellison syndrome
Tagamet] and ranitidine [Zantac]) and the proton pump inhibitors (for example, lansoprazole [Prevacid] and omeprazole [Prilosec]). The H2 antagonists block the action of histamine on stomach cells, thus reducing stomach acid production. The proton pump inhibitors also block the production of acid by the stomach cells. Proton pump inhibitors are more effective than H2 antagonists […]
A triptan drug for the treatment of migraine. Marketed under the brand name Zomig.
Brand name for zolmitriptan, a triptan drug for the treatment of migraine.