Angioneurotic edema, hereditary: A genetic form of angioedema. (Angioedema is also referred to as Quinke’s disease.) Persons with it are born lacking an inhibitor protein (called C1 esterase inhibitor) that normally prevents activation of a cascade of proteins leading to the swelling of angioedema. Patients can develop recurrent attacks of swollen tissues, pain in the abdomen, and swelling of the voice box (larynx) which can compromise breathing. The diagnosis is suspected with a history of recurrent angioedema. It is confirmed by finding abnormally low levels of C1 esterase inhibitor in the blood. Treatment options include antihistamines and male steroids (androgens) that can also prevent the recurrent attacks. Also called hereditary angioedema.
- Angiomyxoma, aggressive
Angiomyxoma, aggressive: A slow-growing tumor of stromal cells which occurs primarily in the genital and pelvic regions. This tumor is much more common in women. It can range from relatively small tumors to football-size masses in the pelvis. The histologic appearance of the tumor under the microscope is rather distinctive. Treatment consists of surgical excision […]
Angiopathy: Disease of the arteries, veins, and capillaries. There are two types of angiopathy: microangiopathy and macroangiopathy. In microangiopathy, the walls of small blood vessels become so thick and weak that they bleed, leak protein, and slow the flow of blood. For example, diabetics may develop microangiopathy with thickening of capillaries in many areas, including […]
Angioplasty: Procedure with a balloon-tipped catheter to enlarge a narrowing in a coronary artery. Also called Percutaneous Transluminal Coronary Angioplasty (PTCA).
Angiosarcoma: A form of tissue cancer (sarcoma) that arises in the lining of blood vessels. Angiosarcomas tend to be aggressive, recur locally, and spread widely. Predisposing factors include lymphedema (as from a radical mastectomy), radiotherapy, foreign materials (such as steel and plastic) in the body, and environmental agents (such as arsenic solutions used to spray […]
Angiostatin: A fragment of a protein, plasminogen, that is involved in blood clotting. Angiostatin is normally secreted by tumors, and it appears to halt the process of developing new blood vessels, which is necessary to tumor development.