Antisense: In molecular biology, the strand complementary to a coding sequence of a nucleic acid.
Antisense DNA is the non-coding strand complementary to the coding strand in double-stranded DNA. The antisense strand serves as the template for messenger RNA (mRNA) synthesis.
Antisense RNA is the non-coding strand complementary to a coding sequence of mRNA, a molecule involved in translating genetic instructions into proteins. Antisense RNA hybridizes with and inactivates mRNA.
Antisense drugs are based on the fact that antisense RNA hybridizes with and inactivates mRNA. These drugs are short sequences of RNA that attach to mRNA and stop a particular gene from producing the protein for which it holds the recipe. Antisense drugs are being developed to treat lung cancer, diabetes and diseases such as arthritis and asthma with a major inflammatory component.
- Antisense DNA
Antisense DNA: DNA normally has two strands, i.e., the sense strand and the antisense strand. In double-stranded DNA, only one strand codes for the RNA that is translated into protein. This DNA strand is referred to as the antisense strand. The strand that does not code for RNA is called the sense strand. Another way […]
- Antisense drug
Antisense drug: A medication containing part of the non-coding strand of messenger RNA (mRNA), a key molecule involved in the translation of DNA into protein. Antisense drugs hybridize with and inactivate mRNA. This stops a particular gene from producing the protein for which it holds the recipe. Antisense drugs have been developed or are “in […]
- Antisense mRNA
Antisense mRNA: An mRNA (messenger RNA) transcript that is complementary to endogenous mRNA. Antisense mRNA is the noncoding strand complementary to the coding sequence of mRNA. Introducing a transgene coding for antisense mRNA is a strategy used to block expression of a gene of interest.
Antisepsis: Prevention of infection by inhibiting or arresting the growth and multiplication of germs (infectious agents). Antisepsis implies scrupulously clean and free of all living microorganisms. From the Greek roots anti- meaning against + sepsis against putrefaction = literally, against putrefaction.
Antiseptic: Something that discourages the growth microorganisms. By contrast, aseptic refers to the absence of microorganisms.