Childhood ataxia with central nervous system hypomyelinization.: An inherited brain disease that occurs mainly in children and follows a chronic progressive course with additional episodes of rapid deterioration following stress from febrile infection or minor head trauma.
The disease is due to mutations in either of two genes — in either the EIF2B5 gene on chromosome 3q27 or the EIF2B2 gene on chromosome 14q24. These two genes encode the epsilon and beta subunits, respectively, of the translation initiation factor eIF2B. Since eIF2B plays an essential role in the regulation of translation under different conditions, including stress, this may explain the rapid deterioration under stress.
The disease is also known as leukoencephalopathy with vanishing white matter (VWM).
- Childhood liver cancer
Childhood liver cancer: Primary cancer of the liver (cancer that starts in the liver) in children, a relatively rare malignancy in children. There are 2 main types of primary liver cancer in children — hepatoblastoma and hepatocellular carcinoma. Hepatoblastomas usually occur before 3 years of age, whereas the incidence of hepatocellular carcinoma varies little with […]
- Childhood translocation 11 leukemia
Childhood translocation 11 leukemia: A new type of childhood leukemia in which a piece of chromosome 11 has been translocated (broken off and attached itself to another chromosome). Children with this type of leukemia have a particularly poor prognosis (outlook). They usually have very high white blood counts and a high frequency of central nervous […]
- Children of the dark
Children of the dark: Term applied sometimes to children with xeroderma pigmentosum, a genetic disease with such extraordinary sensitivity to sunlight that ordinary sun exposure results in the development of skin cancer at a very early age. Children with xeroderma pigmentosum (XP) can only play outdoors safely after nightfall.
- Children of the night
Children of the night: Term applied sometimes to children with xeroderma pigmentosum, a genetic disease with such extraordinary sensitivity to sunlight that ordinary sun exposure results in the development of skin cancer at a very early age. Children with xeroderma pigmentosum (XP) can only play outdoors safely after nightfall.
- Children's immunizations
Vaccinations given to children. In the US, it is currently recommended that all children receive vaccination against the following unless the child has special circumstances, such as a compromised immune system or a neurological disorder: Diphtheria, tetanus, and pertussis (whooping cough), as separate vaccinations or in combination as DPT Haemophilus influenzae type B (HIB) Hepatitis […]