Cox-1: Cyclooxygenase-1, an enzyme that acts to speed up the production of certain chemical messengers, called prostaglandins, in a variety of areas of the body such as the stomach, kidneys, and sites of inflammation. In the stomach, prostaglandins promote the production of a protective natural mucus lining. They also interact within certain cells that are responsible for inflammation and other functions.
- Cox-1 inhibitor
Cox-1 inhibitor: An agent that inhibits the action of the enzyme cox-1 (cyclooxygenase-1). The common anti-inflammatory drugs such as aspirin, ibuprofen, and naproxen block the action of both cox-1 and cox-2. Cox-1 inhibitors can reduce inflammation, but they may also decrease the natural protective mucus lining of the stomach. Therefore, these medications can cause stomach […]
Cox-2: Cyclooxygenase-2, an enzyme that acts to speed up the production of certain chemical messengers, called prostaglandins that play a key role in in promoting inflammation. When cox-2 activity is blocked, inflammation is reduced. Unlike cox-1, cox-2 is active only at the site of inflammation, not in the stomach.
- Cox-2 inhibitor
Cox-2 inhibitor: An antiinflammatory drug that selectively blocks the cox-2 enzyme. Blocking this enzyme impedes the production of the chemical messengers that cause the pain and swelling of arthritis inflammation. Cox-2 inhibitors do not pose as great a risk of injuring the stomach or intestines as drugs that block cox-1. An example of a cox-2 […]
- Coxa valga
Coxa valga: Outward curvature of the hip. Malformation of the hip at birth, such as coxa valga, can increase one’s risk for development of osteoarthritis of the hip in later life
- Coxa vara
Coxa vara: Inward curvature of the hip. Malformation of the hip at birth, such as coxa vara, can increase one’s risk for development of osteoarthritis of the hip in later life.