In genetics, a statistical estimate of whether two loci (the sites of genes) are likely to lie near each other on a chromosome and are therefore likely to be inherited together as a package.
LOD stands for logarithm of the odds (to the base 10). A LOD score of three or more is generally taken to indicate that two gene loci are close to each other on the chromosome. (A LOD score of three means the odds are a thousand to one in favor of genetic linkage).
- Loeys-Dietz syndrome
An inherited syndrome characterized by aortic aneurysms and other blood vessel abnormalities in children. The condition is often associated with other birth defects. The aortic aneurysms of Loeys-Dietz syndrome are prone to rupture at a smaller size than other aneurysms, with early identification of the condition and surgical intervention critical for survival.
The disease caused by the eye worm known as loa loa, a parasite that lives in humans and other primates. People contract the parasite when bitten by infected deer flies. The larvae of the worm enter the bloodstream and later develop into adult worms. Symptoms may not appear for months or years after the bite […]
- Library, genomic
A collection of clones that is made from a set of randomly generated overlapping DNA fragments and that represents the entire genome of an organism. Also known as clone bank.
- Library, cDNA
A collection of DNA sequences generated from mRNA (messenger RNA) sequences. This type of DNA library contains only DNA that codes for proteins and does not include any non-coding DNA.
- Library, arrayed
In genetics, arrayed libraries of DNA clones are used for many purposes, including screening for a specific gene or genomic region of interest as well as for physical mapping. An arrayed library consists of (in technical terms) individual primary recombinant clones (which are hosted in phage, cosmid, YAC, or another vector) that have been placed […]