Phocomelia


A birth defect in which the hands and feet are attached to abbreviated arms and legs. The term comes from phoco (meaning ‘seal’) and melia (meaning ‘limb’), to indicate that a limb is like a seal’s flipper, as in exposure of the developing fetus to thalidomide. Phocomelia may also, in some cases, be genetic.

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    An enzyme that liberates phosphate under alkaline conditions and is made in liver, bone, and other tissues. Alkaline phosphatase can be measured in a routine blood test. Abnormally high serum levels of alkaline phosphatase may indicate bone disease, liver disease, or bile duct obstruction.

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    An enzyme that catalyzes the splitting of a phospholipid molecule by the addition of water. Also called a lecithinase. There are a number of phospholipases. They are grouped on the basis of the specific chemical bond they split. The phospholipases include phospholipase A1 (PLA1), phospholipase A2 (PLA2), phospholipase C, and phospholipase D.


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