EIAATH
enhancement of imipramine antidepressant activity by thyroid hormone
arthur j. prange jr. m.d.1, ian c. wilson m.b., d.p.m.2, archie m. rabon m.d.3, , and morris a. lipton ph.d., m.d.1
1 professors of psychiatry, university of north carolina school of medicine, chapel hill, n. c. 27514
2 research psychiatrist, north carolina department of mental health
3 resident in psychiatry, dorothea dix hospital, raleigh, n. c.
twenty euthyroid patients with r-t-rded depression were studied to determine the possible role of alterations in thyroid function in the etiology and treatment of depression. a battery of tests was administered regularly to measure change. patients responded better to usual doses of imipramine when 25 µg. of l-triiodothyronine (t3) was administered daily. t3 was physiologically active, altering protein-bound iodine values and accelerating ankle reflex time. a possible explanation, based on relevant data from animal experiments, is that imipramine may elevate effective biogenic concentration, while t3 increases receptor sensitivity.
loosing it has caused a huge eiaath to the minds of many!
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