what are you DOING with your life?

means the same thing as:
what is wrong with you?
are you stupid?
are you high?

basically used if you don’t understand how someone could ask a really stupid question.
or if they will not leave you alone.
girl 1: the sun goes around the earth, right?

girl 2: ohmigawd what are you doing with your life?

boy: keeps taking girl’s phone while she’s working

girl: “f-cking knock it off!”

boy: puts phone back on table, waits a few seconds & looks away, then takes phone again

girl: wrestles with boy for her phone “oh my effing god, what are you doing with your life?!”

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