An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts (thrombocytopenia).
The abnormal antibodies are directed against phospholipids. (Phospholipids are fats that contains phosphorous). APLS can occur by itself (primary) or be caused by an underlying condition (secondary), such as systemic lupus erythematosus. About a third of persons with primary APLS have heart valve abnormalities.
Antiphospholipid antibodies reduce the levels of annexin V, a protein that binds phospholipids and has potent anticoagulant activity. The reduction of annexin V levels is thought to be a possible mechanism underlying the increased tendency of blood to clot and the propensity to pregnancy loss characteristic of the antiphospholipid antibody syndrome.
- Syndrome, Apert (acrocephalosyndactyly)
An inherited disorder with abnormalities of the skull and face and the hands and feet. There is premature closure of the sutures of the skull (craniosynostosis). This results in an abnormal head shape, which is unusually tall but short from front to back, and an abnormally shaped face with shallow eye sockets and underdevelopment of […]
- Syndrome, atypical measles (AMS)
An altered expression of measles, AMS begins suddenly with high fever, headache, cough, and abdominal pain. The rash may appear 1 to 2 days later, often beginning on the limbs. Swelling (edema) of the hands and feet may occur. Pneumonia is common and may persist for 3 months or more. AMS occurs in persons who […]
- Syndrome, autoimmune polyglandular (APS)
replacing the various hormones that are in short supply, giving insulin for the diabetes, treating the yeast infections, etc. However, there is no known cure yet for APS. The prognosis (outlook) depends on whether the critical hormone deficiencies are remedied and especially whether the infections can be successfully controlled. APS goes by a confusing array […]
- Syndrome, Barlow
Barlow syndrome is mitral valve prolapse (also known as “click murmur syndrome”), the most common heart valve abnormality, affecting 5%-10% of the world population. Most patients have no symptoms and require no treatment. However, the condition can be associated with fatigue and/or palpitations. The mitral valve prolapse can often be detected by a doctor during […]
- Syndrome, battered child
an infant’s inconsolable crying, feeding difficulties, a toddler’s failed toilet training, and exaggerated parental perceptions of acts of “disobedience” by the child. Children can be neglected and abused by parents, other caregivers, or society. Child abuse should be reported, investigated and evaluated. The treatment and prevention of child abuse include a support group structure coupled […]