‘When you hear hoof beats, think of horses, not zebras.’ For example, when someone develops a mild transient cough, a virus infection is the most logical and likely cause, and tuberculosis is a zebra.
Zeta-chain-associated protein kinase 70. A member of the protein tyrosine kinase family, ZAP-70 is normally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling. ZAP-70 is expressed in T cells and tumors of T-cell lineage. A high level of ZAP-70 expression appears restricted to T-cell […]
- Z chromosome
A sex chromosome in certain animals, such as chickens, turkeys, and moths. In humans, males are XY and females XX, but in animals with a Z chromosome, males are ZZ and females are WZ.
Pertaining to genetic cause of a disease or condition. For example, BRCA 1 and BRCA2 are genes that, when mutated, are responsible for many cases of cancer of the breast. Therefore, these genes are pathogenetic.
- Pseudoxanthoma elasticum
(Abbreviated PXE). A genetic disorder characterized by degeneration of elastic fibers and tiny areas of calcification in the skin, back of the eyes (retinae), and blood vessels. PXE can be inherited as an autosomal dominant or recessive trait and can occur sporadically in the absence of a family history of the disease. Small yellow-white raised […]